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Baihuasheshecao( Oldenlandia)---白花蛇舌草(powder100g/bottle)

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Baihuasheshecao is the whole plant of Oldenlandia diffusa (whild.) Roxb., pertaiing to Rubiaceae. It is collected in summer and fall. It is washed, sun dried, and then cut into slices. The raw form is used.

[ Medicinal Properties ]: Slightly bitter, sweet and cold; relate to stomach, large intestine and small intestine merridians.

[ Medicinal Efficacies ]: Clear heat, relieve toxicity; excrete damp and relieve stranguria.

[ Usage and Dosage ]: 15-60 g. Alsoit is used externally.

[ Precautions ]: Be cautions with deficiency-cold of spleen and stomach.
 
[ Clinical Applications ]: 1. Abscess, swelling, sores, toxin, swollen and sore throat and bites by poisonous snakes      Pound fresh baihuasheshecao to paste externally or combined with Jinyinhua, Lianqiao and Yejuhua to treat abscess, swelling, sores and toxin. It treats abdominal pain due to intestinal abscess, combined with Hongteng, Baijiangcao and Mudanpi. For swollen and sore throat, it is combined with Huangqin, Xuanshen and Nanlangen. Pound the fresh one to take juice for oral administration and paste the dregs on the wound, or combined with Banzhilian, Zihuadiding and Zaoxiu, to treat bites by poisonous snake.
 
2. Heat stranguria astringent pain, damp-heat and jaundice     By itself it treats dribbling urination with astringent pain due to damp-heat in bladder or combined with Baimaogen, Cheqiancao and Shiwei.
 
For it can clear heat and relieve toxicity , in recent year, it is used to treat various cancers such as gastric cancer, esophageal carcinoma and  rectal cancer.

白花蛇舌草为茜草科植物白花蛇舌草Oldenlandia diffusa (willd.) Roxb.的全草。产于福建、广西、广东、云南、浙江、江苏、安徽等省.夏、秋二季采收,洗净.或晒干,切段,生用。
      
【药性】微苦、甘,寒。归胃、大肠、小肠经。       
 
【功效】清热解毒,利湿通淋。       
 
【应用】        1.痈肿疮毒,咽喉肿痛,毒蛇咬伤。本品苦寒,有较强的清热解毒作用,用治热毒所致诸证,内服外用均可。如单用鲜品捣烂外敷,治疗痈肿疮毒,也可以本品与金银花、连翘、野菊花等药同用;用治肠痈腹痛,常与红藤、败酱草、牡丹皮等药同用;若治咽喉肿痛,多与黄芩、玄参、板蓝根等药同用;若用治毒蛇咬伤,可单用鲜品捣烂绞汁内服或水煎服,渣敷伤口,疗效较好,亦可与半枝莲、紫花地丁、蚤休等药配伍应用。        近年利用本品清热解毒消肿之功,已广泛用于各种癌证的治疗。       
 
 2.热淋涩痛。本品甘寒,有清热利湿通淋之效,单用本品治疗膀胱湿热,小便淋沥涩痛,亦常与白茅根、车前草、石韦等同用。       
 
此外,本品既能清热又兼利湿,尚可用于湿热黄疸。       
 
【用法用量】煎服,15~60g。外用适量。       
 
【使用注意】阴疽及脾胃虚寒者忌用。       
 
【现代研究】        1.化学成分:本品全草含三十一烷、豆甾醇、熊果酸、齐墩果酸、β-谷甾醇、β-谷甾醇-D-葡萄糖苷、对香豆酸等。       
 
 2.药理作用:本品在体外对金黄色葡萄球菌和痢疾杆菌有微弱抑制作用;在体内能刺激网状内皮系统增生,促进抗体形成,使网状细胞、白细胞的吞噬能力增强,从而达到抗菌、抗炎的目的;本品对兔实验性阑尾炎的治疗效果显著,可使体温及白细胞下降,炎症吸收;其粗制剂体外实验,在高浓度下对艾氏腹水癌、吉田肉瘤和多种白血病癌细胞均有抑制作用,但实验性治疗无明显抗癌作用;给小鼠腹腔注射白花蛇舌草液可以出现镇痛、镇静及催眠作用;尚有抑制生精能力和保肝利胆的作用。       
 
 3.临床研究:据报道白花蛇舌草尚可用于多种疾病,如:以本品与西洋参、菌灵芝、黄芪、蛇莓等药组方,治疗慢性乙肝132例,均获良效;另用本品与虎杖、板蓝根、黄精、黄芪并配合西药,治疗慢性乙肝98例,总有效率94.9%(时珍国医国药2000,12:1140) ;如用本品提取物(主要成份为黄酮类化合物)制成针剂静滴,配合化疗治疗非淋巴细胞白血病19例,有效率为94.7%,(河南中医药学刊2001,4:38);以本品为主随临床症状辨证用药,水煎,在上午9~10时、下午3~4时之间服用,治疗慢性萎缩性胃炎癌前病变86例,总有效率达85.88%,也可用本品当茶水饮用,长期服用无毒副作用(福建中医药2001,3:37);用本品注射液4ml肌注,1日2次,治疗肺炎、胆囊炎、单纯性阑尾炎、盆腔炎等感染性疾病304例,总有效率92.22%(实用中医内科杂志1998,2:19);近代以本品解毒消肿之功,单用或制成各种制剂广泛用于食管癌、胃癌、直肠癌、肝癌、宫颈癌、绒毛膜癌、膀胱癌、鼻咽癌、肺癌、淋巴肉瘤以及白血病等多种癌症,均可使临床症状得到改善或基本消失(抗癌治验本草1994:265)。
此外据记载,本品尚可用于类风湿性关节炎、慢性肾炎、复发性口腔炎、副睾郁积症以及痤疮等。     
 
   4.不良反应:本品用量在30~60g时,未见明显毒性和副作用,个别病例连续服药后有口干现象;其注射液大剂量静注,可使白细胞数轻度下降,停药后可恢复正常。偶见红色丘疹和呼吸困难等过敏反应,停药后缓解。       

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