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Buguzhi (Malaytea Scurfpea Fruit/Semen psoraleae)---补骨脂

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This medicinal is the dried ripe fruit of Psoralea corylifolia L(Fam.Leguminosae). It is excavated when the fruits become ripe and dried by natural sunlight. It is utilized in its unprocessed, stir-baked, or stir-baked with salt water form.

[ Medicinal Properties ]: Bitter, pungent and warm; relate to kidney and spleen meridians.

[ Medicinal Efficacies ]: Warm and in invigorate kidney yangl improve qi reception and stop diarrhea.

[ Clicinal Applications ]: 1. Kidney deficiency syndrome, pain and cold sensation in knees and lumbus, spermatorrhea, enuresis and frequenturination     For impotence, it is prescribed with Tusizi and Chenxiang, as in the Buguzhi Pills; for pain in knees and lumbus with cold sensation due to declination of kidney yang with invasion by wind-cold, it is prescribed with Duzhong and Gutaorou as in the Qing's Pills; for spermtorrhea, it is combined with Buguzhi and Halite in the same dose, and ground into powder for oral administration. By itself, it is baked and processed into powder for swallows to treat children enuresis.

2.Cough and dyspnea due to deficiency cold   In this case, it is used in combination with Hutaorou and honey. For that due to consumptive disease, it is combined with Renshen and Muxiang.

3. Deficiency of spleen and kidney yang, diarrhea before dawn    In this case, it is used in combination with Roudoukou, Wuzhuyu and Wuzhuyu and Wuweizi, as in the Sishen Pills.

[ Usage and Dosage ]: 5-15g.

[ Precautions ]: It is warm and dry and has the effect to damage yin and promote fire. So it is contraindicated with yin deficiency with effulgent fire or constipation.

[ Side Effects ]: Renal disorders may occur after the rats being drenched with bakuchiol at the doses of 0.125, 0.25, 0.5 or 1.0. Large doses may cause progressive renal impairment.

补骨脂为豆科植物补骨脂Psoralea corylifolia L.的成熟果实。主产于陕西、河南、山西、江西、安徽、广东、四川、云南等地。栽培或野生,以河南、四川等地较多。秋季果实成熟时采收,晒干。生用,炒或盐水炒用。

       【药性】苦、辛,温。归肾、脾经。        【功效】补肾壮阳,固精缩尿,温脾止泻,纳气平喘。       
 
【应用】        1.肾虚阳痿、腰膝冷痛。本品苦辛温燥,善壮肾阳暖水脏,常与菟丝子、胡桃肉、沉香等同用,治肾虚阳痿,如补骨脂丸(《和剂局方》);与杜仲、胡桃肉同用,治肾虚阳衰,风冷侵袭之腰膝冷痛等,如青娥丸。       
 
2.肾虚遗精、遗尿、尿频。本品兼有涩性,善补肾助阳,固精缩尿,单用有效,亦可随证配伍它药。如治滑精,以补骨脂、青盐等分同炒为末服(《三因方》);单用本品炒,为末服,治小儿遗尿,如破故纸散(《补要袖珍小儿方论》);与小茴香等分为丸,治肾气虚冷,小便无度,如破故纸丸(《魏氏家藏方》)。       
 
 3.脾肾阳虚五更泄泻。本品能壮肾阳、暖脾阳、收涩以止泻,与肉豆蔻、生姜、大枣为丸,如二神丸(《普济本事方》);或上方加吴茱萸、五味子,均治五更泄如四神丸(《证治准绳》)。       
 4.肾不纳气,虚寒喘咳。本品补肾助阳,纳气平喘,多配伍胡桃肉、蜂蜜等,可治虚寒性喘咳,如治喘方(《医方论》);或配人参、木香等治疗虚喘痨嗽(《是斋医方》)。       
 
【用法用量】煎服,5~15g。       
 
 【使用注意】本品性质温燥,能伤阴助火,故阴虚火旺及大便秘结者忌服。       
 
 【古籍摘要】        1.《药性论》:“治男子腰疼膝冷囊湿,逐诸冷顽痹,止小便利,腹中冷。”       
 
2.《开宝本草》:“治五劳七伤,风虚冷,骨髓伤败,肾冷精流及妇人血气堕胎。”       
 
 3.《本草经疏》:“补骨脂,能暖水脏,阴中生阳,壮火益士之要药也。”       
 
【现代研究】        1.化学成分:含香豆素类、黄酮类及单萜酚类。       
 
 2.药理作用:复方补骨脂冲剂对垂体后叶素引起的小鼠急性心肌缺血有明显的保护作用,补骨脂对由组胺引起的气管收缩有明显扩张作用,补骨脂酚有雌激素样作用,能增强阴道角化,增强子宫重量,补骨脂是通过调节神经和血液系统,促进骨髓造血,增强免疫和内分泌功能,从而发挥抗衰老作用。       
 
 3.临床研究:将复方补骨脂软膏涂于患处,治疗外阴白斑有效(山西中医药杂志,1993,22,(4):286);补骨脂、益智仁研末分包,晨起以米汤送服,用治疗遗尿(湖南医药杂志,1998,(1):34)。       
 
4.不良反应:补骨脂总油、补骨脂酚和异补骨脂素,小鼠分别灌服补骨脂酚0.125、0.25、0.5、1.0,可引起肾脏病变,大剂量可见进行性肾损害。       

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