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Wujiapi ( Cortex Acanthopanacis )---五加皮(powder100g/bottle)

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The source is from the root cortex of Acanthopanax gracilistylus W.W.Smith, family Araliaceae. It is called Nanwujiapi conventionally. It is dug and collected in the summer and autumn, dried in the sun, cut into thick pieces and the crude one is used for medication.

[ Medicinal Properties ]: Pungent, bitter and warm; relate to liver and kidney meridians.

[ Medicinal Efficacies ]: Dispel wind-damp; tonify the liver and kidney; strengthen the tendons and bones.

[ Usage and Dosage ]: 4.5-9g. It can be soaked in wine, or added into pill or powder.

[ Annotation ]: Wujiapi can be divided into two kinds including southern ones and northern ones. Northern wujiapi is from the root cortex of Periploca sepium Bge.,family Asclepiadaceae. (Called xiangjiapi , seen in the chapter on dampdraining diuretic) . It is toxic and should not be confounded with southern Wujiapi.
 
[ Clinical Appliations ]: 1. Bi-syndrome of wind-dampness   It has the actions of dispelling wind-damp and tonifying as well. So it is especially stuitable for the elderly and weakness with prolonged diseases. For bi-syndrome of wind-dampness manifested as aching pain of lumbar region and knees and spasms of tendons, it can be used alone or prepared with wind in combinatin with Danggui, Niuxi and Diyu, etc.
 
2. Flaccidity of tendons and bones and retarded ambulation of children     For falccidity of tendons and bone dues to deficiency of liver and kidney, it is usually used together with Duzhong and Niuxi, etc. For retarded ambulation of children, it is used in combinatin with Guiban, Niuxi and Mugua, etc.,such as in Wujiapi Powder.
 
3. Edema and beri-beri     For edema and dysuria, it is usually used in combination with Fulingpi, Dafupi,Shengjiangpi and Digupi,etc.,such as in Wujiapi Powder.

五加皮为五加科植物细柱五加Acanthopanax gracilistylusW.W.Smith的干燥根皮。习称“南五加皮”。主产于湖北、河南、安徽等地。夏、秋采挖,剥取根皮,晒干。切厚片,生用。
      
【药性】辛、苦,温。归肝、肾经。     【功效】袪风湿,补肝肾,强筋骨,利水。       
 
【应用】        1.风湿痹证。本品辛能散风,苦能燥湿,温能袪寒,且兼补益之功,为强壮性袪风湿药,尤宜于老人及久病体虚者。治风湿痹证,腰膝疼痛,筋脉拘挛,可单用或配当归、牛膝、地榆等,如五加皮酒(《本草纲目》);亦可与木瓜、松节同用,如五加皮散(《沈氏尊生书》)。       
 
2.筋骨痿软,小儿行迟,体虚乏力。本品有温补之效,能补肝肾,强筋骨。又常用于肝肾不足,筋骨痿软者,常与杜仲、牛膝等配伍,如五加皮散(《卫生家宝》);治小儿行迟,则与龟甲、牛膝、木瓜等同用,如五加皮散(《保婴撮要》)。       
 
 3.水肿,脚气。本品能温肾而除湿利水。治水肿,小便不利,每与茯苓皮、大腹皮、生姜皮、地骨皮配伍,如五皮散(《和剂局方》);若风寒湿壅滞之脚气肿痛,可与远志同用,如五加皮丸(《瑞竹堂经验方》)。       
 
【用法用量】煎服,4.5~9g;或酒浸、入丸、散服。       
 
【古籍摘要】        1.《神农本草经》:“主心腹疝气腹痛,益气,疗躄,小儿不能行,疽疮阴蚀。”      
 
  2.《名医别录》:“主男子阴痿,囊下湿,小便余沥,女人阴痒及腰脊痛,两脚疼痹风弱,五缓,虚羸,补中益精,坚筋骨,强志意,久服轻身耐老。”       
 
3.《本草思辨录》:“五加皮,宜下焦风湿之缓证。若风湿搏于肌肤,则非其所司。古方多浸酒、酿酒及酒调末服之,以行药势。”       
 
 【现代研究】        1.化学成分:本品含丁香苷,刺五加苷B1,右旋芝麻素,16α-羟基-(一)-贝壳松-19-酸,左旋对映贝壳松烯酸,β-谷甾醇,β-谷甾醇葡萄糖苷,硬脂酸,棕榈酸,亚麻酸,维生素A、B1,挥发油等。        2.药理作用:五加皮有抗炎、镇痛、镇静作用,能提高血清抗体的浓度、促进单核巨噬细胞的吞噬功能,有抗应激作用,能促进核酸的合成、降低血糖,有性激素样作用,并能抗肿瘤、抗诱变、抗溃疡,且有一定的抗排异作用。       
 
【其他】同属植物作五加皮入药的尚有:无梗五加 Acanthopanax sessiliflorus (Rupr. et Maxim.) Seem.、红毛五加 A.giraldii Harms、糙叶五加 A. henryi (Oliv.) Harms、藤五加 A. leucorrhizus (Oliv.) Harms 、乌蔹莓五加 A. cissifolius (Griff.) Harms等。        古代所用的五加皮包括五加科五加属的多种植物,除上述品种外,似亦应包括刺五加Acanthopanax senticosus (Rupr. et Maxim.) Harms在内,而《中国药典》现已将其作为独立的药物收载。现在使用的五加皮药材,有南五加皮和北五加皮之分。
 
北五加皮为萝藦科植物杠柳Periploca sepium Bge的根皮(见利水渗湿药),《中国药典》以“香加皮”之名收入。
南五加皮与北五加皮科属不同,功效有异,且北五加皮有毒,不应混用。       

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