
The source is from the seed of Pharbitis nil ( L. ) Choisy or Pharbitis purpurea (L.) Voigt, family Convolvulaceae. The medicial material is collected in the end of autumn when the fruits are ripe and the fruit shell does not split open, and dried in the sun. The raw or stir-baked forms are utilized as medicine.
[ Medicinal Properties ]: Bitter, cold,toxic; relate to the lung, kidney and large intestine meridians.
[ Usage and Dosage ]: 3-6g. It is takenorally. If it is added to pill or powder for, 1.5-3g. The fried form can moderate the medicinal's properties.
[ Precautions ]: It should be contraindicated in pregnant women. It is incompatible with Badou and Badoushuang.
[ Side Effects ]: Large dose can induce vomiting, abdominal pain, diarrhea, bloody and mucoid stool. It can aslo damage the kidney toinduce hematuresis. Even it can damage CNS to induce language disorder and coma,etc.
[ Clinical Applications ]: 1. Edema and tympanites It has actions of purging fluid inferior to Gansui and Jingdaji. For edema and tympanites, it can be pounded into powder alone, or ground into powder together with Xiaohuixiang prepared with Jiangzhi. It is also used together with Gansui and Jiangdaji, such as in Zhouche Pill.
2. Cough and dyspnea due to phelgm and fluid For cough and dyspnea due to stagnation of qi in the lung and phlegm and fluid manifested as edema in the face and eyes, it can be gruond into powder together with Dahuang and Binglang.
3. Abdominal pain due to accumulation of worms For abdominal pain due to ascariasis and taeniasis , etc., it can be ground into powder together with Binglang and Shijunzi for oral use.
牵牛子为旋花科植物裂叶牵牛Pharbitis nil(L.) Choisy或圆叶牵牛Pharbitis purpurea (L.) Voigt的干燥成熟种子。全国大部分地区均产。秋末果实成熟、果壳未开裂时采收,晒干。生用或炒用,用时捣碎。
【药性】苦,寒。有毒。归肺、肾大肠经。
【功效】泻下逐水,去积杀虫。
【应用】 1.水肿,臌胀。本品苦寒,其性降泄,能通利二便以排泄水湿,其逐水作用虽较甘遂、京大戟稍缓,但仍属峻下逐水之品,以水湿停滞,正气未衰者为宜。治水肿臌胀,二便不利者,可单用研末服(《千金方》);或与茴香为末,姜汁调服(《
儒门事亲》);病情较重者,可与甘遂、京大戟等同用,以增强泻水逐饮之力,如舟车丸(《
景岳全书》)。
2.痰饮喘咳。本品能泻肺气,逐痰饮,用治肺气壅滞,痰饮咳喘,面目浮肿者,可与大黄、槟榔为末服,如牛黄夺命散(《保婴集》)。
3.虫积腹痛。本品能去积杀虫,并可借其泻下通便作用以排除虫体。治蛔虫、绦虫及虫积腹痛者,可与槟榔、使君子同用,研末送服,以增强去积杀虫之功。
【用法用量】煎服,3~9g。入丸、散服,每次1.5~3g。本品炒用药性减缓。 【使用注意】孕妇忌用。不宜与巴豆、巴豆霜同用。
【古籍摘要】 1.《
名医别录》:“主下气,疗脚满水肿,除风毒,利小便。”
2.《
本草纲目》:“逐痰消饮,通大肠气秘风秘,杀虫。”
3.《本草正》:“牵牛,古方多为散丸,若用救急,亦可佐群药煎服,然大泄元气,凡虚弱之人须忌之。”
【现代研究】 1.化学成分:含牵牛子苷、牵牛子酸甲、没食子酸及生物碱麦角醇、裸麦角碱、喷尼棒麦角碱、异喷尼棒麦角碱、野麦碱。
2.药理作用:牵牛子苷在肠内遇胆汁及肠液分解出牵牛子素,刺激肠道,增进蠕动,导致强烈的泻下;其黑丑、白丑泻下作用无区别。在体外实验,黑丑、白丑对猪蛔虫尚有一定驱虫效果。
3.临床研究:据报道,以牵牛子为主或适当配伍还可用于治疗其它多种疾病,如:用二丑30~60g,壁钱若干个,糯米500g。一同加工成粉,每次用粉30g,煮糊吃,治疗淋巴结核30例,均获得痊愈(安徽单验方选集(第1版)·安徽人民出版社,1972.27)。用牵牛子24g(研末,冲),大黄15g(后下),元明粉12g(冲),枳实9g,水煎服,治疗肝硬化腹水,消水作用较满意(首批国家级名老中医效验秘方精选·国际文化出版社,1996.44)。另外,还可用治蛲虫,癫痫等病症。
4.不良反应:本品对人体有毒性,大量使用除直接引起呕吐、腹痛、腹泻及粘液血便外,还可刺激肾脏,引起血尿,严重者可损及神经系统,发生语言障碍、昏迷等。