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Zhusha (Cinnabar)---朱砂

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Product Description

It refers to Cinnabar of sulfide type, mainly containing mercuric sulfide. The medicinal produced in Chenzhou of ancient times (now Yuanling, Human province) is the genuine one. After being mined, the mineral is purified with a magnet to remove the impurity containing iron, and then stones and sands are washed away. It is refined into powder with water, then dried and put into bottles for medication.

[ Medicinal Properties ]: Sweet, slightly cold and toxic ; relate to heart meridian.

[ Medicinal Efficacies ]: Relieve palpitation and calm spirit; clear heat and remove toxin.

[ Clinical Applications ]: 1. Irritability, palpitation, insomnia     For exuberance of heart fire causing irritability, restless fever in chest, palpitation and insomnia, it is combined with Huanglian and Gancao; for those accompanied by deficiency of heart blood, Danggui and Shengdihuang are added, that is Zhusha Anshen Pills; for palpitation due to fright or heart deficiency, it is put into a pig's heart and stewed for oral administration; for deficiency of yin and blood resulting in palpitation and insomnia, Danggui, Baiziren and Suanzaoren are used together.

2. Convulsion, epilepsy      For high fever causing coma and convulsion, it is used with Niuhuang and Shexiang in Angong Niuhuang Pills; for infantile convulsion, with Niuhuang and Quanxie, such as Niuhuang Powder; for epilepsy, sudden coma and convulsion, with Cishi and Shenqu in Cizhu pills.

3. Carbuncle, sore throat and aphthae    It treats carbuncle in combination with Xionghuang and Daji ,such as Zijin Troche; it treats sore throat and aphthae, with Bingpian and Pengsha in Bingpeng Powder for external application.

In addition, it is also used as coat of pills and boluses, strengthening the effect of calming spirit and preventing decaying.

[ Usage and Dosage ]: 0.1-0.5g is usaully used in pill or powder form , not in decoction. It is used externally with appropriate dosage.

[ Precautions ]: Since it is toxic, it cannot be used in large amount for a prolonged time. It contraindicates with abnormal function of liver and kidneys. It avoids being calcined, because mercury can be separated out, which is extremely toxic.

朱砂为硫化物类矿物辰砂族辰砂,主含硫化汞(HgS)。主产湖南、贵州、四川、广西、云南等地,以产于古之辰州(今湖南沅陵)者为道地药材。采挖后,选取纯净者,用磁铁吸净含铁的杂质,再用水淘去杂石和泥沙,照水飞法研成极细粉末,晾干或40℃以下干燥。

       【药性】甘,微寒。有毒。归心经。        【功效】清心镇惊,安神解毒。       
 
【应用】        1.心神不宁,心悸,失眠。本品甘寒质重,寒能降火,重可镇怯,专入心经,既可重镇安神,又能清心安神,为镇心、清火、安神定志之药。可治心火亢盛,内扰神明之心神不宁、惊悸怔忡、烦躁不眠者,宜与黄连、栀子、磁石、麦冬等合用,以增强清心安神之效;若与当归、生地黄、炙甘草等同用,可治心火亢盛,阴血不足之失眠多梦、惊悸怔忡、心中烦热,如朱砂安神丸(《内外伤辨惑论》);阴血虚者,还可与酸枣仁、柏子仁、当归等配伍。       
 
 2.惊风,癫痫。本品质重而镇,略有镇惊止痉之功。故可用治温热病,热入心包或痰热内闭所致的高热烦躁,神昏谵语,惊厥抽搐者,常与牛黄、麝香等开窍、息风药同用,如安宫牛黄丸(《温病条辨》);如治小儿惊风,又常与牛黄、全蝎、钩藤配伍,如牛黄散(《证治准绳》);用治癫痫卒昏抽搐,常与磁石同用,如磁朱丸(《千金方》);若小儿癫痫,可与雄黄、珍珠等药研细末为丸服,如五色丸(《小儿药证直诀》)。       
 
 3.疮疡肿毒,咽喉肿痛,口舌生疮。本品性寒,不论内服、外用,均有清热解毒作用,用治疮疡肿毒,常与雄黄、山慈菇、大戟等同用,如太乙紫金锭(《外科正宗》);若咽喉肿痛,口舌生疮,可配冰片、硼砂外用,如冰硼散(《外科正宗》)。       
 
【用法用量】内服,只宜入丸、散服,每次0.1~0.5g;不宜入煎剂。外用适量。       
 
【使用注意】本品有毒,内服不可过量或持续服用,孕妇及肝功能不全者禁服。入药只宜生用,忌火煅。       
 
【古籍摘要】        1.《神农本草经》:“养精神,安魂魄,益气明目。”       
 
2.《本草纲目》:“治惊癎,解胎毒痘毒,驱邪疟”       
 
 3.《本草从新》:“泻心经邪热,镇心定惊,……解毒,定癫狂。”       
 
【现代研究】        1.化学成分:本品主要成分为硫化汞(HgS),含量不少于96%。此外,含铅、钡、镁、铁、锌等多种微量元素及雄黄、磷灰石、沥青质、氧化铁等杂质。       
 
2.药理作用:朱砂能降低大脑中枢神经的兴奋性,有镇静催眠、抗惊厥、抗心律失常作用,外用有抑制和杀灭细菌、寄生虫作用。       
 
 3.临床研究:据报道,用磁朱丸配合小剂量冬眠灵(磁朱丸治疗老年白内障有显著疗效(中华眼科杂志,1957,1:1);用朱砂30g,法半夏15g,丁香、生甘草各6g,冰片0.6g,制成散剂,治疗神经性呕吐属热、属实证者,获良好效果(江苏中医杂志,1982,2:30)。另有用朱砂等治疗心律失常、病毒性心肌炎、小儿夜啼、牙痛、口腔炎等。       
 
 4.不良反应:朱砂为无机汞化合物,汞与人体蛋白质中巯基有特别的亲和力,高浓度时,可抑制多种酶的活性,使代谢发生障碍,直接损害中枢神经系统。急性中毒的症状表现为尿少或尿闭、浮肿、甚至昏迷抽搐、血压下降或因肾功能衰竭而死亡。慢性中毒者口有金属味、流涎增多、口腔粘膜充血、溃疡、牙龈肿痛、出血、恶心、呕吐、腹痛腹泻、手指或全身肌肉震颤、肾脏损害可表现为血尿、蛋白尿、管型尿等。朱砂中毒的主要原因:一是长期大剂量口服引起蓄积中毒;二是挂衣入煎剂时,因其不溶于水而沉附于煎器底部,经长时间受热发生化学反应,可析出汞及其他有毒物质,增加毒性。所以必须控制剂量、中病即止。服药期间,应避免与含甲基结构的药物(如茶碱、心得安等)以及含溴、碘的物质(如溴化物、碘化物、巴氏合剂、三溴合剂、海藻、海带等)同服。并避免高脂饮食或饮酒,合理用药,以保证用药安全。朱砂中毒的早期可催吐,并给予解毒剂。严重者,可对症处理。       

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