
Zicao is the dried root of Arnebia eufhroma ( Royle ) Johnst., Lithospermum erythrorhizon Sieb. et Zucc., and arnebia guttata Bunge, pertaining to Boraginaceae. It is collected in spring and fall. After the earth and sands are removed, it is dried. The raw form is used.
[ Medicinal Properties ]: Sweet, salty and cold; relate to heart and liver meridians.
[ Medicinal Efficacies ]: Cool blood, activate blood; relieve toxicity and promote eruption.
[ Usage and Dosage ]: 5-10g. Also it can be processed into paste or processed with plant oil to make extract for external application.
[ Precautions ]: For it can cause mild diarrhea, avoid with spleen deficiency with loose stool.
[ Clinical Applications ]: 1. Blood heat, prosperous toxin, macula of dark color, measles failing to erupt Zicao treat echymosis due to warm toxinosis and macula of dark color due to blood heat with prosperous toxin, usually combined with Chishao, Chantui and Gancao; for example in zicao Kuaiban Decoction. It treats measles failing to erupt with dark color, sore and swollen throat, combined with Niubangzi, Shandougen and Lianqiao; for example in Zicao Xiaodu Decoction.
2. Sore and ulcers, eczema and burns It treats abscess, swelling, sores and ulcers, combined with Jinyinhua, Lianqiao and Pugongying. For ulceration of long time, it is used in combinaiton with Danggui, Baizhi and Xuejie; for example in Shengji Yuhong Paste. In case of eczema, it is in combination with Huanglian and Huangbo. For burns, its plant oil extract is externally applied on the affected part, or in combination with Huangbo, Mudanpi and Dahuang, Mixed with sesame oil to make paste for external application.
紫草为紫草科植物新疆紫草Arnebia euchroma (Royle) Johnst.、紫草Lithospermum erythrorhizon Sieb. et Zucc.或内蒙紫草 A. guttata Bunge的干燥根,主产于辽宁,湖南,河北,新疆等地。春、秋二季采挖,除去泥沙,干燥。生用。
【药性】甘、咸,寒。归心,肝经。
【功效】清热凉血,活血,解毒透疹。
【应用】 1.温病血热毒盛,斑疹紫黑,麻疹不透。本品咸寒入肝经血分,有凉血活血、解毒透疹之功。治温毒发斑,血热毒盛,斑疹紫黑者,常配赤芍、蝉蜕、甘草等药用,如紫草快斑汤(《
张氏医通》);若配牛蒡子、山豆根、连翘等药用,可治麻疹不透,疹色紫暗,兼咽喉肿痛者,如紫草消毒饮(《
张氏医通》);若配黄芪、升麻、荆芥等,可治麻疹气虚,疹出不畅,如紫草解肌汤(《证治准绳》)。
2.疮疡,湿疹,水火烫伤。本品甘寒能清热解毒,咸寒能清热凉血,并能活血消肿,治痈肿疮疡,可配银花、连翘、蒲公英等药用;若配当归、白芷、血竭等药,可治疮疡久溃不敛,如生肌玉红膏(《
外科正宗》)。治湿疹,可配黄连、黄柏、漏芦等药用,如紫草膏(《仁斋直指方》。若治水火烫伤,可用本品以植物油浸泡,滤取油液,外涂患处,或配黄柏、丹皮、大黄等药,麻油熬膏外搽。
【用法用量】煎服,5—10g。外用适量,熬膏或用植物油浸泡涂搽。 【使用注意】本品性寒而滑利,脾虚便溏者忌服。
【古籍摘要】 1.《
神农本草经》:“主心腹邪气,五疸,补中益气,利九窍,通水道。” 2.《
本草纲目》:“紫草,其功长于凉血活血,利大小肠。故痘疹欲出未出,血热毒盛,大便闭涩者用之,已出而紫黑便闭者亦可用。若已出而红活,及白陷大便利者,切宜忌之。”
【现代研究】 1.化学成分:本品含紫草素(紫草醌)、紫草烷、乙酰紫草素、去氧紫草素、异丁酰紫草素、二甲基戊烯酰紫草素、β,β-二甲基丙烯酰紫草素等。
2.药理作用:本品煎剂、紫草素、二甲基戊烯酰紫草素、二甲基丙烯酰紫草素对金黄色葡萄球菌、大肠杆菌、枯草杆菌等具有抑制作用;紫草素对大肠杆菌、伤寒杆菌、痢疾杆菌、绿脓杆菌及金黄色葡萄球菌均有明显抑制作用;其乙醚、水、乙醇提取物均有一定的抗炎作用;新疆产紫草根煎剂对心脏有明显的兴奋作用;新疆紫草中提取的紫草素及石油醚部分有抗肿瘤作用;本品有抗生育、解热等作用。
3.临床研究:用紫草、甘草水煎服,治玫瑰糠疹154例,有效率为97.4%,治愈率为80.5%(临床皮肤科杂志,1983,3:158);用紫草200g,入香油750g中,炸枯过滤,外涂宫颈及阴道上端,治疗子宫颈糜烂100例,痊愈48例,显效8例,好转4例(中西医结合杂志,1986,4:237);用紫草20—30g,水煎服,每日3次,对62例淋病尿道狭窄患者进行7—25天治疗,痊愈50例,好转12例(中医杂志,1996,5:263)。此外,用本品制剂或配伍其他药物还可治疗烧伤、肝炎、扁平疣、口腔粘膜病、银屑病、静脉炎、过敏性紫癜、顽固性溃疡、化脓性中耳炎、阴道炎等疾病。
附药 紫草茸 为紫胶虫科昆虫紫胶虫Laccifer Lacca kerr.在树枝上所分秘的胶质物。主产于云南、四川、台湾等地,西藏及广东也产。7-8有间采收,置干燥、阴凉通风处直至干燥。性味苦寒,功能清热、凉血,解毒,治麻疹、斑疹透发不畅、疮疡肿毒、湿疹,作用与紫草相似,但无滑肠通便之弊。用量1.5—6g,或研末服。外用适量,研末撒。