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Yangjinhua (Datura Flower )---洋金花

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It is the flower of Datura metel L.,family Solanaceae. The flowers are collected from July to September when they are in full bloom. They are dried in the sunshie or in low temperature. The raw or those processed with ginger juice or liquor are used.

[ Medicinal Properties ]: Pungent, warm, toxic; relate to lung and liver meridians.

[ Medicinal Efficacies ]: Relieve cough and dyspnea; anesthetize to stop pain; relieve spasm and convulsion.

[ Clinical Applications ]: 1. Asthma and cough        It can relieve cough and dyspnea with anesthetic effects, so it is effective for adults or the old contracted by cough and dyspnea without sputum or with scanty sputum and failed to be cured by other medicines. It is ground into powder for oral administration, or made into cigarettes with tobacco leaves for smoking. Now it is often combined in compound recipes to treat chronic bronchitis accompanied with dyspnea and bronchial asthma.

2. Cardiodynia, abdominal pain, wind-dampness with arthralgia, traumatic injuries       It is effective along or combined with chuanwu, Caowu and Jianghuang to treat them. For traumatic injuries with arthralgia and pain, it is decocted for oral administration or for washing or external application.

3. Anesthesia     It is used as anesthetic form the ancient times, in combination with Caowu, Chuanwu and Jianghuang , such as Zhenggu Mayao Formula. In modern times, it or its extract-scopolamine is made into herbal anesthetic, extensively used for surgical operations.

4. Epilepsy, chronic infantile convulsion        It is combined with Quanxie, Tianma and Tiangnanxing.

[ Usage and Dosage ]: 0.2-0.6g, usually in pill or powder form, is taken for oral adminstratin. The dosage in cigarettes should not be more than 1.5g in one day. An appropriate dosage is decocted for washing or ground into powder for external application.

[ Precautions ]: Over dosage should be avoided since it is toxic. It cannot be used to treat external contraction, glaucoma, hypertension and tachycardia. It is used cautiously for pregnant women and those with weak constitution

[ Side Effects ]: Over dosage may cause poisoning, especially when used for infants. The symptoms and signs of poisoning are as follows; one category are those caused by interruption of functions of parasympathetic nerve, such as dry mouth, vomiting, nausea, erubescence, quicker heart rate and respiration, delirium and blurred vision; another category are those of central nervous system, such as instability of gait, drowsiness, disturbance of consciousness, phrenitis, incontinence of defecation and urination, mania, even convulsion and physiological hyperreflexia, and some patients may have fever, leucocytosis and neutrophilic leucocytosis. In severe case, death may be caused by numbness of respiratory centre.

洋金花为茄科植物白曼陀罗Darura metel L.的花。主产于江苏、浙江、福建、广东等地。7~9月花盛开时采收,晒干或低温干燥。生用或姜汁、酒制用。

       【药性】辛,温。有毒。归肺、肝经。        【功效】平喘止咳,麻醉镇痛,止痉。       
 
【应用】        1.哮喘咳嗽。本品为麻醉镇咳平喘药,对成人或年老咳喘无痰或痰少,而他药乏效者用之。可散剂单服,或配烟叶制成卷烟燃吸;现也常配入复方用治慢性喘息性支气管炎,支气管哮喘。       
 
 2.心腹疼痛,风湿痹痛,跌打损伤。本品有良好的麻醉止痛作用,可广泛用于多种疼痛疾病。单用即有效,也可配川草乌,姜黄等同用。治痹痛,跌打疼痛,除煎汤内服外,还可煎水外洗或敷。       
 
3.麻醉。本品自古就已用作麻醉药,常与草乌、川乌、姜黄等同用,如整骨麻药方(《医宗金鉴》)。近代以本品为主,或单以本品提取物东莨菪碱制成中药麻醉药,广泛用于各种外科手术麻醉,效果满意。       
 
 4.癫痫,小儿慢惊风。本品有解痉止搐之功,可配全蝎、天麻、天南星等息风止痉药同用以增强药效。       
 
【用法用量】内服,O.2~0.6g,宜入丸、散剂;作卷烟吸,一日量不超过1.5g。外用适量,煎汤洗或研末外敷。       
 
【使用注意】本品有毒,应控制剂量。外感及痰热咳喘、青光眼、高血压、心动过速者禁用;孕妇、体弱者慎用。       
 
【古籍摘要】        1.《履巉岩本草》:“治寒湿脚,面上破,生疮,晒干为末,用少许贴患处。”       
 
2.《本草纲目》:“诸风及寒湿脚气,煎汤洗之;又主惊痫及脱肛;并入麻药。”        3.《本草便读》:“止疮疡疼痛,宣痹着寒哮。”       
 
【现代研究】        1.化学成分:白曼陀罗花含莨菪烷型生物碱。其中主要包括东莨菪碱(天仙子碱)、莨菪碱(天仙子胺)、阿托品。       
 
2.药理作用:东莨菪碱对大脑皮层和皮层下某些部位主要是抑制作用,使意识丧失,产生麻醉。但对延髓和脊髓则有不同程度的兴奋作用;有一定的镇痛作用。对支气管及胃肠平滑肌有松弛作用。有阿托品样解除血管痉挛,改善微循环及组织器官的血流灌注而有抗休克作用。有散瞳,调节眼麻痹及抑制腺体分泌的作用。洋金花生物碱能明显提高血液和大脑皮质超氧化物岐化酶(SOD)活性,降低丙二醛(MDA)含量。生物碱小剂量时,兴奋迷走神经中枢使心率减慢;剂量较大时,则阻滞心脏M胆碱受体,使心率加快。较高浓度的莨菪类具有抗心律失常作用和非特异性的钙通道阻滞作用。       
 
 3.临床研究:止喘灵注射液(主要成分为洋金花和麻黄),肌注配伍抗生素治婴幼儿哮喘,总有效率达96.7%,明显高于氨茶碱口服对照组(温州医学院学报,1993,4:239);用花仙子胶囊(洋金花、制马钱子、花旗参、仙灵脾),早晚服,治强直性脊柱炎,总有效率达92.7%,疗效优于消炎痛(广西医学,1994,2:156);洋金花注射液,每晚睡前肌注,治疗5例变态反应性亚败血症,均痊愈。(新中医,1988,11:35);用含有洋金花总碱的中药穴位贴膜(晕呕宁)防治运动病眩晕102例,总有效率为83.23%。对美尼尔氏综合征眩晕和放化疗所致的呕吐亦有一定的缓解作用(北京中医学院学报,1993,6:40);       
 
 4.不良反应:食用过量多致中毒,小儿较为多见。中毒症状和体征可归纳为两类:一类为副交感神经功能阻断症状,包括口干、恶心呕吐、皮肤潮红、心率、呼吸增快、瞳孔散大、视物模糊等;二类以中枢神经系统症状为主:步态不稳、嗜睡、意识模糊、谵妄、大小便失禁、狂躁不安甚至抽搐、生理反射亢进等,个别病人可出现发热、白细胞升高、中性粒细胞增加。严重者可因呼吸中枢麻痹而死亡。解毒措施:4~6小时以内者,以清水或1:5000~1:2000高锰酸钾溶液洗胃。超过4小时者,则应以硫酸镁导泻,并配合葡萄糖注射液静脉滴注,无尿者可静脉注射20%甘露醇250ml或给速尿40~80mg。拮抗剂可用毛果芸香碱或毒扁豆碱,或用抗胆碱酯酶药新斯的明。
 
此外,须进行对症处理及抗生素预防感染,并采取保温措施。中药解救可用甘草30g,绿豆60g,煎汤频服;或用绿豆120g,银花60g,连翘30g,甘草15g 煎水服。亦可用防风,桂枝煎汤服。       
 
 【其他】本品的叶与种子均有止痛作用,均以东莨菪碱为主要成分。同属植物毛曼陀罗D.innoxia Mill.、紫曼陀罗D.tatula L.、欧曼陀罗D.stramonium L.等,均与本品同功。

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