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Badou ( Croton Fruit )---巴豆

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Product Description

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The source is from the dried ripe fruits of Croton tiglium L., family Euphorbiaceae. It is collected in the autumn when the fruits are ripe. The seeds or made into frostlike powder are for medicinal use.

[ Medicinal Properties ]: Pungent, heat, extremely toxic; relate to the stomach and large intestine meridians.

[ Medicinal Efficacies ]: Purge drastically, expel fluid; eliminate phlegm, comfort throat; corrode wound as external use.

[ Usage and Dosage ]: In pill or powder form, 0.1-0.3g is taken at one time. Processing it into a frostlike powder reduces its toxiceity. The appropriate amount is used externally.

[ Precautions ]: Contraindicated in pregnant women and the weakness . It is incompatible with Qianniuzi.

[ Side Effects ]: It can induce hemolysis and necrosis of cells; it can stimulate and corrode mucosa of gastrium and intestine drastically to induce nausea, vomiting and abdominal pain, even hemorrhagic gastritis manifested as bloody stool with mucosa; it can induce acute dermatitis, sore throat, vomiting, angina ofintestine, diarrhea with rice water-like stool, headache, dizziness, respiratory or circulatory failure to death. External use of the frostlike powder can induce contact dermatitis manifested as pustule rashes and blister, etc.
 
[ Clinical Applications ]: 1. Constipation due to cold accumulation       It can purge cold accumulation drastically, which is suitable for cold evil, food retention, constipation, abdominal fullness and distending pain. It can be made into frostlike powder in capsules or together with Dahuang and Ganjiang, such as in Sanwu Beiji Pill.
 
2. Abdominal dropsy and tympanites       It can be made into pill together with Xingren. For abdominal dropsy in the later stage of cirrhosis of bilharziasis, it is combined with Jiangfan and Shenqu in modern times to make up Hanbajiang fan Wan.
 
3. Inflammatin of throat due to phlegm obstruction      It is peeled and put into throat by thread in ancient times. In modern times, for laryngemphraxis due to diphtheritis and laryngitis, the frostlike powder of Badou can be blown into throat to  induce voiting and promote to expel phlegm, which can relieve the throat. For profuse phlegm obstruction, chest stuffiness and thoracic accumulation of cold, it can be combined with Beimum Jiegeng, such as in Sanwu Bai Powder. For infantile cold accumultion, milk or food retention and profuse phlegm, it is combined with Liushenqu, Tiannanxing and Zhusha, such as in Baochi Powder.
 
4.Suppuration in abscess, scabies and tinea      It is oil can be extracted and mixed with powder of Xionghuang, Qingfen for external use. It can also be decocted into plaster for external application together with Ruxiang, Moyao and Mubiezi, etc.
 
[ Medicinal Comparison ]: Similarities: Badou and Dahuang both have intense action of purgation,which is suitable for constipation of stagnation type.
 
Differences: Badou is mainly indicated for the treatment of urgent constipation of cold accumulation, due to its properties of pungent and heat. For other types of stagnation, it is usually made into frostlike powder and used in a small amount. Dahuang is mainly indicated to treat constipation of heat stagnation, due to its properties of being bitter and cold. For constipation of cold accumulation, it must be combined with medicinals which has a warm or hot nature, such as Fuzi.

巴豆为大戟科植物巴豆Croton tiglium L.的干燥成熟果实。主产于四川、广西、云南、贵州等省。秋季果实成熟时采收。用仁或制霜。
      
【药性】辛,热;有大毒。归胃、大肠经。       
 
【功效】峻下冷积,逐水退肿,祛痰利咽,外用蚀疮。       
 
【应用】        1.寒积便秘。本品辛热,能峻下冷积,开通肠道闭塞。可单用巴豆霜装入胶囊服,或配大黄、干姜制丸服,适用于寒邪食积,阻结肠道,大便不通,腹满胀痛,病起急骤,气血未衰者,如三物备急丸(《金匮要略》)。       
 
2.腹水臌胀。本品峻泻,有较强的逐水退肿作用。用治腹水臌胀,可用巴豆配杏仁为丸服(《肘后方》)。近代用本品配绛矾、神曲为丸,即含巴绛矾丸,用治晚期血吸虫病肝硬化腹水。       
 
3.喉痹痰阻。本品能祛痰利咽以利呼吸。治喉痹痰涎壅塞气道,呼吸困难,甚则窒息欲死者,可单用巴豆,去皮,线穿纳入喉中,牵出即苏;近代用于白喉及喉炎引起喉梗阻,用巴豆霜吹入喉部,引起呕吐,排出痰涎,使梗阻症状得以缓解。治痰涎壅塞、胸膈窒闷、肢冷汗出之寒实结胸者,常与贝母、桔梗同用,如三物小白散(《伤寒论》)。此外,小儿痰壅、乳食停积甚则惊悸者,可用本品峻药轻投,可祛痰、消积,常与胆南星、朱砂、六神曲等同用,如万应保赤散(《全国中药成药处方集》)。       
 
 4.痈肿未溃、疥癣恶疮。本品外用有蚀腐肉、疗疮毒作用。治痈肿成脓未溃者,常与乳香、没药、木鳖子等熬膏外敷,以蚀腐皮肤,促进破溃排脓;治恶疮,单用本品炸油,以油调雄黄、轻粉末,外涂疮面即可。       
 
【用法用量】入丸、散服,每次0.1~0.3g.。大多数制成巴豆霜用,以减低毒性。外用适量。        【使用注意】孕妇及体弱者忌用。不宜与牵牛子同用。       
 
【鉴别用药】巴豆辛热燥烈,要力刚猛,峻下冷积,开通闭塞,主治冷积便秘重症;大黄苦寒泄降,峻下实热,荡涤胃肠,主治实热积滞便秘急症。       
 
【古籍摘要】        1.《神农本草经》:“破癥瘕结聚,坚积,留饮痰癖,大腹水胀,荡涤五脏六腑,开通闭塞,利水谷道,去恶肉。”       
2.《名医别录》:“疗女子月闭,烂胎,金疮脓血不利,丈夫阴,杀斑蝥毒。”       
 3.《本草通玄》:“巴豆禀阳刚雄猛之性,有斩关夺门之功,气血未衰,积邪坚固者,诚有神功,老羸衰弱之人,轻妄投之,祸不旋踵。巴豆、大黄,同为攻下之剂,但大黄性冷,腑病多热者宜之;巴豆性热,脏病多寒者宜之。故仲景治伤寒传里恶热者,多用大黄。东垣治五积属脏者,多用巴豆。       
 
【现代研究】        1.化学成分:含巴豆油34~57%,其中含巴豆油酸和甘油脂。油中尚含巴豆醇二脂和多种巴豆醇三脂。此外,还含巴豆毒素、巴豆苷、生物碱、β-谷甾醇等。       
 
 2.药理作用:巴豆油外用,对皮肤有强烈刺激作用。口服半滴至1滴,即能产生口腔、咽及胃粘膜的烧灼感及呕吐,短时期内可有多次大量水泻,伴有剧烈腹痛和里急后重;巴豆煎剂对金黄色葡萄球菌、白喉杆菌、流感杆菌、绿脓杆菌均有不同程度的抑制作用;巴豆油有镇痛及促血小板凝集作用。巴豆提取物对小鼠腹水型与艾氏腹水癌有明显抑制作用;巴豆油、巴豆树脂和巴豆醇脂类有弱性致癌活性。       
 
3.临床研究:据报道,以巴豆为主或适当配伍还可用于治疗其它多种疾病,如:用巴豆粉胶囊合茵陈大柴胡汤,治疗胆囊炎、胆石症均取得满意疗效(辽宁中医杂志,1980,8:43)。用巴豆与黄蜡配伍,制成巴豆丸,囫囵吞下,可治疗急慢性化脓性骨髓炎、鼻窦炎(湖南医药杂志,1979,1:39;河南医药,1983,34:247)。用巴豆制剂对甲状腺癌的疗效也较显著(健康报,1987,11:10)。另外,还可用于痹证、面神经麻痹、急性肠梗阻及小儿鹅口疮等。       
 
 4.不良反应:本品具有强烈的毒性,其含巴豆毒蛋白及巴豆油。巴豆毒蛋白是一种细胞原浆毒,能溶解红细胞,并使局部细胞坏死;巴豆油系一种峻泻剂,对胃肠道粘膜具有强烈的刺激和腐蚀作用,可引起恶心、呕吐与腹痛,重则发生出血性胃肠炎,大便内可带血和粘膜。对肾亦有刺激作用。皮肤接触巴豆油后,能引起急性皮炎。中毒表现:症状为咽喉肿痛、呕吐、肠绞痛、腹泻,甚则腐蚀肠壁,出现霍乱样米汤样大便,头痛,眩晕,皮肤冷湿,脱水,呼吸或循环衰竭而死亡。外用巴豆霜可产生接触性皮炎,局部烧灼成脓疱状红疹,水疱等症状。       

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